Overview
The Bhattacharyya Lab employs an integrative approach to understand the molecular mechanism for the regulation and activation of kinase signalling pathways in the context of learning and memory, and cognitive impairments in Down Syndrome.
Overview
The Bhattacharyya Lab employs an integrative approach to understand the molecular mechanism for the regulation and activation of kinase signalling pathways in the context of learning and memory, and cognitive impairments in Down Syndrome.
Overview
The Bhattacharyya Lab employs an integrative approach to understand the molecular mechanism for the regulation and activation of kinase signalling pathways in the context of learning and memory, and cognitive impairments in Down Syndrome.
The hattacharyya Lab
Selected Publications
Research articles
Moitrayee Bhattacharyya, Young Kwang Lee, Serena Muratcioglu, Baiyu Qiu, Priya Nyayapati, Howard Schulman, Jay T. Groves, John Kuriyan, Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation. eLife, 9, e53670 (2020). PMCID: PMC7141811
Deepti Karandur, Moitrayee Bhattacharyya, Zijie Xia, Young Kwang Lee, Serena Muratcioglu, Darren McAffee, Ethan McSpadden, Baiyu Qiu, Jay T Groves, Evan R Williams, John Kuriyan, 2020. Breakage of the oligomeric camkii hub by the regulatory segment of the kinase. eLife 2020;9:e57784 DOI: 10.7554/eLife.57784 (2020). PMCID: PMC7538161.
Moitrayee Bhattacharyya, Margaret M. Stratton, Catherine C. Going#, Ethan McSpadden, Yongjian Huang, Anna C. Susa, Anna Elleman, Yumeng Melody Cao, Nishant Pappireddi, Pawel Burkhardt, Christine Gee, Tiago Barros, Howard Schulman, Evan R. Williams, John Kuriyan, Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II, eLife, 5, e13405 (2016).PMCID: PMCID4859805
Margaret Stratton, Il-Hyung Lee, Moitrayee Bhattacharyya, Sune M Christensen, Luke H Chao, Howard Schulman, Jay T Groves, John Kuriyan, Activation-triggered subunit exchange between CamKII holoenzyme facilitates the spread of kinase activity, eLife, 3, e01610 (2014). PMCID: PMCID3920281
Bhattacharyya M, Gupta K, Gowd KH, and Balaram P, Rapid mass spectrometric determination of disulfide connectivity in peptides and proteins, Mol BioSystems, 9, 1340 (2013). doi: 10.1039/C3MB25534D.PMID: 23467691
Bhattacharyya M, Bhat CR, and Vishveshwara S, An automated approach to network features of protein structure ensembles, Protein Science, 22, 1399 (2013). PMCID: PMC3795498
Bhattacharyya M and Vishveshwara S, Probing the allosteric mechanism in pyrrolysyl-tRNA synthetase using energy-weighted network formalism, Biochemistry, 50, 6225 (2011). doi: 10.1021/bi200306u. PMID: 21650159
Reviews
Bhattacharyya M, Karandur D, Kuriyan J. Structural Insights into the Regulation of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII). Cold Spring Harb Perspect Biol., 2019, doi: 10.1101/cshperspect.a035147. PMCID: PMC7263085
Bhattacharyya M, Ghosh S, and Vishveshwara S, Protein Structure and Function: Looking through the Network of Side-Chain Interactions, Current Protein and Peptide Science, 17, 4 (2016). PMID: 26412788
Halder A, Anto A, Subramanyan V, Bhattacharyya M, Vishveshwara S and Vishveshwara S (2020) Surveying the Side-Chain Network Approach to Protein Structure and Dynamics: The SARS-CoV-2 Spike Protein as an Illustrative Case. Front. Mol. Biosci. 7:596945. doi: 10.3389/fmolb.2020.596945 PMCID: PMC7775578
#
#
#
#
#
#
#
#
#
#
#
equal contributions